Immunology , 8th Edition

By David Male, MA, PhD, Jonathan Brostoff, MA, DM, DSc(Med), FRCP, FRCPath, David Roth, MD, PhD and Ivan Roitt, DSc HonFRCP FRCPath FRS
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Immunology, 8th Edition makes it easy for you to learn all the basic and clinical concepts you need to know for your courses and USMLEs. This medical textbook's highly visual, carefully structured approach makes immunology simple to understand and remember.

Key Features
  • Understand the building blocks of the immune system - cells, organs and major receptor molecules - as well as initiation and actions of the immune response, especially in a clinical context.
  • Visually grasp and retain difficult concepts easily thanks to a user-friendly color-coded format, key concept boxes, explanatory diagrams, and over 190 photos to help you visualize tissues and diseases.
  • Put concepts into practice. "Critical Thinking Boxes" and 25 online cases encourage you to "think immunologically" while anchoring your understanding of immunology through clinical application.
  • Gauge your mastery of the material and build confidence with high-yield style chapter-opening summaries and case-based and USMLE-style questions that provide effective chapter review and quick practice for your exams.
  • Access the full contents online at where you'll find the complete text and illustrations, USMLE-style questions, clinical cases, and much more!

New to this Edition
  • Get the depth of coverage you need in a smaller, more manageably sized book. Through meticulous editing and reorganization, primary material remains in the book while more specialized and clinical material has been moved online.
  • Master the most cutting-edge concepts in immunology. Thorough updates throughout provide the timely knowledge you need ace your exams.
ISBN 9780323080583
Table of Content

Preface vii

List of Contributors ix


Components of the Immune System 1

1 Introduction to the Immune System 3

David Male

2 Cells, Tissues, and Organs of the

Immune System 17

Peter M Lydyard and Nino Porakishvili

3 Antibodies 51

Roy Jefferis

4 Complement 71

B Paul Morgan

5 T Cell Receptors and MHC Molecules 89

David B Roth


Modes of Immune Response 107

6 Mechanisms of Innate Immunity 109

David Male

7 Mononuclear Phagocytes in Immune

Defense 125

Luisa Martinez-Pomares and

Siamon Gordon

8 Antigen Presentation 143

David Male

9 Cell Cooperation in the Antibody

Response 157

Joseph C Marini and Kalpit A Vora

10 Cell-mediated Cytotoxicity 171

Victoria Male

11 Regulation of the Immune Response 183

David Bending

12 Immune Responses in Tissues 199

David Male


Defense Against Infectious Agents 209

13 Immunity to Viruses 211

Persephone Borrow and Anthony A Nash

14 Immunity to Bacteria and Fungi 223

Gregory J Bancroft

15 Immunity to Protozoa and Worms 243

Richard J Pleass

16 Primary Immunodeficiencies 263

Luigi D Notarangelo

17 AIDS, Secondary Immunodeficiency

and Immunosuppression 277

Dean H Kedes and Lisa A Nichols

18 Vaccination 289

Colin Casimir


Immune Responses Against Tissues 305

19 Immunological Tolerance 307

Thomas Kamradt

20 Autoimmunity and Autoimmune

Disease 323

James E Peters and David A Isenberg

21 Transplantation and Rejection 341

Andrew J T George

22 Immunity to Cancers 355

Pramod K Srivastava



Hypersensitivity 369

23 Immediate Hypersensitivity (Type I) 371

Thomas A E Platts-Mills

24 Hypersensitivity (Type II) 393

David Male

25 Hypersensitivity (Type III) 405

David P D'Cruz

26 Hypersensitivity (Type IV) 419

Warwick J Britton

Appendices online

1. Major Histocompatibility Complex

2. CD System

3. The Major Cytokines

4. Human Chemokines and Their Receptors

Critical thinking: Explanations 433

Glossary 445

Index 455



Author Information By David Male, MA, PhD, Professor of Biology, Department of Life Sciences, The Open University, Milton Keynes, UK; Jonathan Brostoff, MA, DM, DSc(Med), FRCP, FRCPath, Professor Emeritus of Allergy and Environmental Health, King's College London, London, UK; David Roth, MD, PhD, Simon Flexner Professor and Chair of Pathology and Laboratory Medicine, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA and Ivan Roitt, DSc HonFRCP FRCPath FRS, Hon Director, Middlesex Centre for Investigative & Diagnostic Oncology, School of Health & Social Sciences, Middlesex University, London, UK
Trim 276h x 219w mm
Pages 472
Publication Date 28-09-2012
Stock Status Please allow 3 - 4 weeks for delivery.
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