Drug Discovery and Development, 2nd Edition
The modern pharmacopeia has enormous power to alleviate disease, and owes its existence almost entirely to the work of the pharmaceutical industry. This book provides an introduction to the way the industry goes about the discovery and development of new drugs. The first part gives a brief historical account from its origins in the mediaeval apothecaries’ trade, and discusses the changing understanding of what we mean by disease, and what therapy aims to achieve, as well as summarising case histories of the discovery and development of some important drugs. The second part focuses on the science and technology involved in the discovery process: the stages by which a promising new chemical entity is identified, from the starting point of a medical need and an idea for addressing it. A chapter on biopharmaceuticals, whose discovery and development tend to follow routes somewhat different from synthetic compounds, is included here, as well as accounts of patent issues that arise in the discovery phase, and a chapter on research management in this environment. The third section of the book deals with drug development: the work that has to be undertaken to turn the drug candidate that emerges from the discovery process into a product on the market.
The modern pharmacopeia has enormous power to alleviate disease, and owes its existence almost entirely to the work of the pharmaceutical industry. This book provides an introduction to the way the industry goes about the discovery and development of new drugs. The first part gives a brief historical account from its origins in the mediaeval apothecaries’ trade, and discusses the changing understanding of what we mean by disease, and what therapy aims to achieve, as well as summarising case histories of the discovery and development of some important drugs. The second part focuses on the science and technology involved in the discovery process: the stages by which a promising new chemical entity is identified, from the starting point of a medical need and an idea for addressing it. A chapter on biopharmaceuticals, whose discovery and development tend to follow routes somewhat different from synthetic compounds, is included here, as well as accounts of patent issues that arise in the discovery phase, and a chapter on research management in this environment. The third section of the book deals with drug development: the work that has to be undertaken to turn the drug candidate that emerges from the discovery process into a product on the market.
New to this edition
-
The second edition has a new editor: Professor Raymond Hill ● non-executive director of Addex Pharmaceuticals, Covagen and of Orexo AB ● Visiting Industrial Professor of Pharmacology in the University of Bristol ● Visiting Professor in the School of Medical and Health Sciences at the University of Surrey ● Visiting Professor in Physiology and Pharmacology at the University of Strathclyde ● President and Chair of the Council of the British Pharmacological Society ● member of the Nuffield Council on Bioethics and the Advisory Council on Misuse of Drugs.
New to this edition:
- Completely rewritten chapter on The Role of Medicinal Chemistry in the Drug Discovery Process.
- New topic - DMPK Optimization Strategy in drug discovery.
- New chapter on Scaffolds: Small globular proteins as antibody substitutes.
- Totally updated chapters on Intellectual Property and Marketing
- 50 new illustrations in full colour
Key Features
-
The definitive introduction to how a pharmaceutical company goes about its business of discovering and developing drugs.
The second edition has a new editor: Professor Raymond Hill ● non-executive director of Addex Pharmaceuticals, Covagen and of Orexo AB ● Visiting Industrial Professor of Pharmacology in the University of Bristol ● Visiting Professor in the School of Medical and Health Sciences at the University of Surrey ● Visiting Professor in Physiology and Pharmacology at the University of Strathclyde ● President and Chair of the Council of the British Pharmacological Society ● member of the Nuffield Council on Bioethics and the Advisory Council on Misuse of Drugs.
New to this edition:
- Completely rewritten chapter on The Role of Medicinal Chemistry in the Drug Discovery Process.
- New topic - DMPK Optimization Strategy in drug discovery.
- New chapter on Scaffolds: Small globular proteins as antibody substitutes.
- Totally updated chapters on Intellectual Property and Marketing
- 50 new illustrations in full colour
Features
- Accessible, general guide to pharmaceutical research and development.
- Examines the interfaces between cost and social benefit, quality control and mass production, regulatory bodies, patent management, and all interdisciplinary intersections essential to effective drug development.
- Written by a strong team of scientists with long experience in the pharmaceutical industry.
- Solid overview of all the steps from lab bench to market in an easy-to-understand way which will be accessible to non-specialists.
From customer reviews of the previous edition:
‘… it will have everything you need to know on this module. Deeply referenced and, thus, deeply reliable.
- Highly Commended in the medicine category of the BMA 2006 medical book competition
- Winner of the Royal Society of Medicine Library Prize for Medical Book of the Year
Author Information
| ISBN Number | 9780702042997 |
|---|---|
| Description Author List | Edited by Raymond G Hill, President, British Pharmacological Society, London, UK |
| Copyright Year | 2012 |
| Edition Number | 2 |
| Format | Book |
| Trim | 189w x 246h (7.44" x 9.68") |
| Imprint | Churchill Livingstone |
| Page Count | 348 |
| Publication Date | 4 Sep 2012 |
| Stock Status | Please allow 10-14 working days for delivery |
eBooks : Built for busy schedules & tailored for your goals.
Affordable knowledge, built for you
Get the resources you need-often at a lower cost than print. Quality content designed to support your goals, without stretching your budget.
Seamless access wherever you are
Always in sync
Tools the make learning stick
Your eBook is ready whenever you are!
1. Check your email for your access code.
2. Sign into or create your VitalSource account and redeem your code.
3. Open your eBook - ready whenever you are!
FAQ
The access code for your new eBook will be sent in your order confirmation email. Your code can also be accessed in your My Account section on the Elsevier webshop. If you do not receive your code within a few minutes, please check your spam folder.
Step-by-step guidance on how to download Bookshelf and also redeem your code can be found here.
The access code for your new eBook does not expire. However, we always suggest redeeming immediately after purchase to start experiencing the benefits of and insights from your purchase. Important to note - the code provided is a single use code and only valid for the edition you purchase. It does not provide access to past nor future editions of the title.
You will have unlimited access to your eBook on the device to which it was downloaded.
Discover the various learning features that our eBooks offer on the Bookshelf® Reader! For example, you can highlight different text passages, create notes and flashcards, have the text read to you, etc. Particularly practical: You can also use your eBooks offline. More information on the learning functions can be found on the Vitalsource page.
Quality is our top priority. That's why we collaborate with the leading eBook reader provider VitalSource. VitalSource has its own eBook reader Bookshelf®, which you can easily download. This reader is very user-friendly and offers more features than other standard readers. For example, you can highlight different text passages, create notes and flashcards, have the text read to you, etc. Particularly practical: You can also use your eBooks offline. More information can be found on the Vitalsource page.
Elsevier offers its eBooks in ePub format, as we believe this format is best suited to display our content ideally on as many devices as possible.
You can return your eBook within 13 days of purchase. eBooks that have been partially printed or flipped through more than 15% are excluded from returns.
Any questions ?
Top Picks from Our Community
E-Book
E-Book
E-Book
E-Book
E-Book
E-Book
E-Book
E-Book
E-Book
E-Book
E-Book
E-Book
E-Book
E-Book
E-Book
E-Book
E-Book
E-Book
E-Book
E-Book
E-Book
E-Book
E-Book
E-Book
E-Book
Contents
SECTION 1
INTRODUCTION AND BACKGROUND
1. The development of the pharmaceutical industry
H P Rang
2. The nature of disease and the purpose of therapy
H P Rang, R G Hill
3. Therapeutic modalities
H P Rang, H LeVine, R G Hill
SECTION 2
DRUG DISCOVERY
4. The drug discovery process: general principles and some case histories
H P Rang, R G Hill
5. Choosing the project
H P Rang, R G Hill
6. Choosing the target
H P Rang, R G Hill
7. The role of information, bioinformatics and genomics
B Robson, R McBurney
8. High-throughput screening
D Cronk
9. The role of medicinal chemistry in the drug discovery process
P Beswick, A Naylor
10. DMPK optimization strategy in drug discovery
P G Ballard, P Brassil, K H Bui, H Dolgos, C Petersson, A Tunek, P J H Webborn
11. Pharmacology: its role in drug discovery
H P Rang
12. Biopharmaceuticals
H LeVine
13. Scaffolds: Small globular proteins as antibody substitutes
D Grabulovski, J Bertschinger
SECTION 3
DRUG DEVELOPMENT
14. Drug development: introduction
H P Rang, R G Hill
15. Assessing drug safety
H P Rang, R G Hill
16. Pharmaceutical developmentT Lundqvist, S Bredenberg
17. Clinical Development – Present and Future
C Keywood
18. Clinical imaging in drug development
P M Matthews
19. Intellectual property in drug discovery and development
P Grubb
20. Regulatory affairs
I Hägglöf, Å Holmgren
21. Marketing the drug
V L Lawton
SECTION 4
FACTS AND FIGURES
22. Drug discovery and development – facts and figures
H P Rang, R G Hill
