Diagnostic Pathology : Hepatobiliary and Pancreas, 4th Edition
This item will be released on 16-07-2026
This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of neoplastic and nonneoplastic diseases of the liver, biliary tree, pancreas, and gallbladder, it incorporates the most recent clinical, pathologic, and molecular knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the fourth edition of Diagnostic Pathology: Hepatobiliary and Pancreas is an essential text for accurate, complete pathology reports, ideal as a day-to-day reference or as a reliable, one-stop training resource.
ISBN :
9780443380228
Publication Date :
16-07-2026
Stock Status :
Available for Pre-Order
This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of neoplastic and nonneoplastic diseases of the liver, biliary tree, pancreas, and gallbladder, it incorporates the most recent clinical, pathologic, and molecular knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the fourth edition of Diagnostic Pathology: Hepatobiliary and Pancreas is an essential text for accurate, complete pathology reports, ideal as a day-to-day reference or as a reliable, one-stop training resource.
Key Features
- Presents clear delineations in challenging diagnoses for both nonneoplastic and neoplastic settings, illustrates novel tumor variants, uses updated terminology and society guidelines, and summarizes the role of molecular findings for diagnosis
- Analyzes hundreds of diagnoses, each of which include critical diagnostic information such as definitions, epidemiology, clinical presentation, macro- and microscopic features, differential diagnoses, and pathologic interpretation pearls
- Details the increasing use of molecular methods to diagnose cholestatic biliary liver conditions and other liver diseases of unknown etiology
- Notes critical recent terminology changes, such as the switch from non-alcoholic fatty liver disease (NAFLD) to metabolic dysfunction-associated steatotic liver disease (MASLD)
- Explains novel variants of hepatocellular tumors and cholangiocarcinoma, and illustrates the integration of genomic findings in establishing the diagnosis and subclassification of tumors
- Features more than 1,400 high-quality print images (with an additional 250+ images in the complimentary eBook), including histology and gross pathology images, full-color medical illustrations, clinical photographs, and radiology images
- Reflects the most recent information from the 6th edition WHO Classification of Tumours, Digestive System Tumours, the American Association for the Study of Liver Disease (AASLD), and the European Association for the Study of the Liver (EASL), including new AASLD guidelines for hepatocellular carcinoma (HCC) and EASL guidelines for cholangiocarcinoma
- Features a templated, highly formatted design; concise, bulleted text; key facts in each chapter; and an extensive index for easy reference
- Includes a complimentary eBook with access to everything in the print version as well as additional text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud; additional digital ancillary content may publish up to 6 weeks following the publication date
Author Information
By Sanjay Kakar, Professor of Pathology, Chief, Gastrointestinal and Hepatobiliary Pathology Service, University of California, San Francisco, San Francisco, California and Maria Westerhoff, MD, Professor of Pathology, Gastrointestinal and Hepatobiliary Section, Assistant Chair of Well-Being and Culture, Department of Pathology, University of Michigan, Ann Arbor, Michigan
| ISBN Number | 9780443380228 |
|---|---|
| Description Author List | By Sanjay Kakar, Professor of Pathology, Chief, Gastrointestinal and Hepatobiliary Pathology Service, University of California, San Francisco, San Francisco, California and Maria Westerhoff, MD, Professor of Pathology, Gastrointestinal and Hepatobiliary Section, Assistant Chair of Well-Being and Culture, Department of Pathology, University of Michigan, Ann Arbor, Michigan |
| Copyright Year | 2027 |
| Edition Number | 4 |
| Format | Book |
| Trim | 216w x 276h (8.50" x 10.875") |
| Illustrations | Approximately 1,650 (1,650 in full color) |
| Imprint | Elsevier |
| Page Count | 552 |
| Publication Date | 16 Jul 2026 |
| Stock Status | Available for Pre-Order |
PART I: LIVER
SECTION 1: INHERITED, METABOLIC, AND DEVELOPMENTAL DISORDERS
Glycogen Storage Disease, Hepatic
Tyrosinemia
Niemann-Pick Disease
Gaucher Disease
Neonatal Hemochromatosis
Porphyrin Metabolism Disorders
Dubin-Johnson Syndrome
Gilbert Disease
Progressive Familial Intrahepatic Cholestasis
Cystic Fibrosis, Hepatic
Hereditary Hemochromatosis
Wilson Disease
Alpha-1-Antitrypsin Deficiency
Congenital Hepatic Fibrosis
Polycystic Liver Disease
Caroli Disease
Lysosomal Lipase Deficiency (Including Wolman Disease)
SECTION 2: INFECTIOUS DISORDERS
Overview of Hepatitis
Acute Viral Hepatitis
Hepatitis B
Hepatitis C
Hepatitis E
Epstein-Barr Virus
Cytomegalovirus
Herpes Simplex Virus
Adenovirus
Pyogenic Abscess
Sepsis In The Liver
Mycobacterium tuberculosis
Atypical Mycobacteria
Cat-Scratch Disease
Candidiasis
Histoplasmosis
Cryptococcosis
Amebiasis
Schistosomiasis
Echinococcosis
Syphilis
SECTION 3: CHRONIC CHOLESTATIC AND AUTOIMMUNE DISORDERS
Autoimmune Hepatitis
Autoimmune Hepatitis Diagnostic Criteria and Grading/Staging Information
Primary Biliary Cholangitis
Primary Sclerosing Cholangitis
Ischemic Cholangitis
Large Bile Duct Obstruction
Liver Involvement in IgG4-Related Disease
Idiopathic Adulthood Ductopenia
SECTION 4: PEDIATRIC CHOLESTATIC DISORDERS
Biliary Atresia
Neonatal Hepatitis
Syndromic Paucity of Intrahepatic Bile Ducts (Alagille Syndrome)
Nonsyndromic Paucity of Intrahepatic Bile Ducts
SECTION 5: DRUG/TOXIN-RELATED HEPATITIS
Drug-Induced Acute Hepatitis
Drug-Induced Acute Hepatic Failure
Drug-Induced Cholestatic Liver Injury
Drug-Induced Granulomatous Hepatitis
Drug-Induced Steatohepatitis/Phospholipidosis
Reye Syndrome
Drug-Induced Cholangitis/Ductopenia
Hepatic Stellate Cell Hyperplasia
SECTION 6: FATTY LIVER DISEASES
Alcoholic Liver Disease
Metabolic Dysfunction-Associated Steatohepatitis
Glycogenic Hepatopathy
Fatty Liver of Pregnancy
SECTION 7: VASCULAR DISORDERS
Portal Venopathy/Portal Sinusoidal Vascular Disorder
Hepatic Venous Outflow Obstruction
Venoocclusive Disease
Amyloidosis
Ischemia
Nodular Regenerative Hyperplasia
SECTION 8: TRANSPLANTATION PATHOLOGY
Ischemia Reperfusion Injury
Antibody-Mediated Rejection
T-Cell-Mediated Rejection (Acute Cellular Rejection)
Chronic Rejection
Central Perivenulitis/Parenchymal Rejection
Hepatic Artery Thrombosis
Graft-vs.-Host Disease
SECTION 9: TUMORS OF THE LIVER
Hepatocellular Adenoma
Focal Nodular Hyperplasia
Regenerative and Dysplastic Nodules
Hepatocellular Carcinoma and Variants
Fibrolamellar Carcinoma
Combined Hepatocellular-Cholangiocarcinoma
Hepatoblastoma
Bile Duct Adenoma
von Meyenburg Complex (Biliary Microhamartoma)
Mucinous Cystic Neoplasm, Liver
Medical Liver Biopsy: Indications and Approach to Diagnosis
Approach to Liver Biopsy for Mass Lesions
Intrahepatic Cholangiocarcinoma
Intrahepatic Cholangiocarcinoma, Histologic Subtypes
Intraductal Papillary Neoplasm of the Bile Duct
Hemangioma
Angiomyolipoma
Hepatic Small Vessel Neoplasm/Anastamosing Hemangioma
Epithelioid Hemangioendothelioma
Infantile Hemangioma
Angiosarcoma
Mesenchymal Hamartoma
Embryonal Sarcoma
Inflammatory Pseudotumor
Segmental Atrophy (Nodular Elastosis)
Hepatectomy Specimen Handling
Tumors Metastatic to Liver
SECTION 10: MISCELLANEOUS HEPATIC DISORDERS
Langerhans Cell Histiocytosis
Hemophagocytic Lymphohistiocytosis
Liver Involvement in Systemic Liver Diseases
PART II: PANCREAS AND BILIARY TRACT
SECTION 1: DEVELOPMENTAL/CONGENITAL
Congenital Pancreatic Cyst
Cystic Fibrosis, Pancreatic
Nesidioblastosis
Choledochal Cyst
SECTION 2: INFLAMMATORY DISORDERS OF THE GALLBLADDER AND EXTRAHEPATIC BILIARY TREE
Cholelithiasis
Acute Cholecystitis
Chronic Cholecystitis
Xanthogranulomatous Cholecystitis
Eosinophilic Cholecystitis
Polyarteritis Nodosa and Other Vasculitides
Parasitic Infection
SECTION 3: NONNEOPLASTIC AND INFLAMMATORY DISORDERS OF THE PANCREAS
Acute Pancreatitis
Chronic Pancreatitis
Autoimmune Pancreatitis
Groove Pancreatitis
Infectious Pancreatitis
Pseudocysts
Diabetes Mellitus
Lymphoepithelial Cyst of the Pancreas
SECTION 4: TUMORS OF THE GALLBLADDER AND EXTRAHEPATIC BILIARY TREE
Mass-Forming Intracholecystic Neoplasm
Carcinoma of Gallbladder
Carcinoma of Extrahepatic Bile Ducts
Squamous/Adenosquamous Carcinoma, Gallbladder
Neuroendocrine Neoplasms of Gallbladder
Granular Cell Tumor
Embryonal Rhabdomyosarcoma
Adenomyoma
Nonneoplastic Polypoid Gallbladder Lesions
Specimen Handling, Gallbladder
SECTION 5: TUMORS OF THE PANCREAS
Pancreatic Intraepithelial Neoplasia
Ductal Adenocarcinoma, Including Histologic Subtypes
Undifferentiated Carcinoma
Adenosquamous Carcinoma, Pancreas
Acinar Cell Carcinoma
Serous Cystadenoma
Acinar Cystic Transformation of the Pancreas
Well-Differentiated Neuroendocrine Tumor, Pancreas
Poorly Differentiated Neuroendocrine Carcinoma, Pancreas
Genomic Diagnosis of Intrahepatic Hepatobiliary Tumors
Role of Genomics in Diagnosis of Pancreaticobiliary Tumors
Simple Mucinous Cyst
Mucinous Cystic Neoplasm, Pancreas
Intraductal Papillary Mucinous Neoplasm
Intraductal Oncocytic Papillary Neoplasm
Intraductal Tubulopapillary Neoplasm
Solid Pseudopapillary Neoplasm
Pancreatoblastoma
Dermoid Cyst
Specimen Handling, Whipple
SECTION 6: TUMORS OF THE AMPULLA
Ampullary Adenoma
Ampullary Adenocarcinoma and Histologic Subtypes
Well-Differentiated Neuroendocrine Tumor, Ampulla
Composite Gangliocytoma/Neuroma and Neuroendocrine Tumor/Gangliocytic Paraganglioma
SECTION 1: INHERITED, METABOLIC, AND DEVELOPMENTAL DISORDERS
Glycogen Storage Disease, Hepatic
Tyrosinemia
Niemann-Pick Disease
Gaucher Disease
Neonatal Hemochromatosis
Porphyrin Metabolism Disorders
Dubin-Johnson Syndrome
Gilbert Disease
Progressive Familial Intrahepatic Cholestasis
Cystic Fibrosis, Hepatic
Hereditary Hemochromatosis
Wilson Disease
Alpha-1-Antitrypsin Deficiency
Congenital Hepatic Fibrosis
Polycystic Liver Disease
Caroli Disease
Lysosomal Lipase Deficiency (Including Wolman Disease)
SECTION 2: INFECTIOUS DISORDERS
Overview of Hepatitis
Acute Viral Hepatitis
Hepatitis B
Hepatitis C
Hepatitis E
Epstein-Barr Virus
Cytomegalovirus
Herpes Simplex Virus
Adenovirus
Pyogenic Abscess
Sepsis In The Liver
Mycobacterium tuberculosis
Atypical Mycobacteria
Cat-Scratch Disease
Candidiasis
Histoplasmosis
Cryptococcosis
Amebiasis
Schistosomiasis
Echinococcosis
Syphilis
SECTION 3: CHRONIC CHOLESTATIC AND AUTOIMMUNE DISORDERS
Autoimmune Hepatitis
Autoimmune Hepatitis Diagnostic Criteria and Grading/Staging Information
Primary Biliary Cholangitis
Primary Sclerosing Cholangitis
Ischemic Cholangitis
Large Bile Duct Obstruction
Liver Involvement in IgG4-Related Disease
Idiopathic Adulthood Ductopenia
SECTION 4: PEDIATRIC CHOLESTATIC DISORDERS
Biliary Atresia
Neonatal Hepatitis
Syndromic Paucity of Intrahepatic Bile Ducts (Alagille Syndrome)
Nonsyndromic Paucity of Intrahepatic Bile Ducts
SECTION 5: DRUG/TOXIN-RELATED HEPATITIS
Drug-Induced Acute Hepatitis
Drug-Induced Acute Hepatic Failure
Drug-Induced Cholestatic Liver Injury
Drug-Induced Granulomatous Hepatitis
Drug-Induced Steatohepatitis/Phospholipidosis
Reye Syndrome
Drug-Induced Cholangitis/Ductopenia
Hepatic Stellate Cell Hyperplasia
SECTION 6: FATTY LIVER DISEASES
Alcoholic Liver Disease
Metabolic Dysfunction-Associated Steatohepatitis
Glycogenic Hepatopathy
Fatty Liver of Pregnancy
SECTION 7: VASCULAR DISORDERS
Portal Venopathy/Portal Sinusoidal Vascular Disorder
Hepatic Venous Outflow Obstruction
Venoocclusive Disease
Amyloidosis
Ischemia
Nodular Regenerative Hyperplasia
SECTION 8: TRANSPLANTATION PATHOLOGY
Ischemia Reperfusion Injury
Antibody-Mediated Rejection
T-Cell-Mediated Rejection (Acute Cellular Rejection)
Chronic Rejection
Central Perivenulitis/Parenchymal Rejection
Hepatic Artery Thrombosis
Graft-vs.-Host Disease
SECTION 9: TUMORS OF THE LIVER
Hepatocellular Adenoma
Focal Nodular Hyperplasia
Regenerative and Dysplastic Nodules
Hepatocellular Carcinoma and Variants
Fibrolamellar Carcinoma
Combined Hepatocellular-Cholangiocarcinoma
Hepatoblastoma
Bile Duct Adenoma
von Meyenburg Complex (Biliary Microhamartoma)
Mucinous Cystic Neoplasm, Liver
Medical Liver Biopsy: Indications and Approach to Diagnosis
Approach to Liver Biopsy for Mass Lesions
Intrahepatic Cholangiocarcinoma
Intrahepatic Cholangiocarcinoma, Histologic Subtypes
Intraductal Papillary Neoplasm of the Bile Duct
Hemangioma
Angiomyolipoma
Hepatic Small Vessel Neoplasm/Anastamosing Hemangioma
Epithelioid Hemangioendothelioma
Infantile Hemangioma
Angiosarcoma
Mesenchymal Hamartoma
Embryonal Sarcoma
Inflammatory Pseudotumor
Segmental Atrophy (Nodular Elastosis)
Hepatectomy Specimen Handling
Tumors Metastatic to Liver
SECTION 10: MISCELLANEOUS HEPATIC DISORDERS
Langerhans Cell Histiocytosis
Hemophagocytic Lymphohistiocytosis
Liver Involvement in Systemic Liver Diseases
PART II: PANCREAS AND BILIARY TRACT
SECTION 1: DEVELOPMENTAL/CONGENITAL
Congenital Pancreatic Cyst
Cystic Fibrosis, Pancreatic
Nesidioblastosis
Choledochal Cyst
SECTION 2: INFLAMMATORY DISORDERS OF THE GALLBLADDER AND EXTRAHEPATIC BILIARY TREE
Cholelithiasis
Acute Cholecystitis
Chronic Cholecystitis
Xanthogranulomatous Cholecystitis
Eosinophilic Cholecystitis
Polyarteritis Nodosa and Other Vasculitides
Parasitic Infection
SECTION 3: NONNEOPLASTIC AND INFLAMMATORY DISORDERS OF THE PANCREAS
Acute Pancreatitis
Chronic Pancreatitis
Autoimmune Pancreatitis
Groove Pancreatitis
Infectious Pancreatitis
Pseudocysts
Diabetes Mellitus
Lymphoepithelial Cyst of the Pancreas
SECTION 4: TUMORS OF THE GALLBLADDER AND EXTRAHEPATIC BILIARY TREE
Mass-Forming Intracholecystic Neoplasm
Carcinoma of Gallbladder
Carcinoma of Extrahepatic Bile Ducts
Squamous/Adenosquamous Carcinoma, Gallbladder
Neuroendocrine Neoplasms of Gallbladder
Granular Cell Tumor
Embryonal Rhabdomyosarcoma
Adenomyoma
Nonneoplastic Polypoid Gallbladder Lesions
Specimen Handling, Gallbladder
SECTION 5: TUMORS OF THE PANCREAS
Pancreatic Intraepithelial Neoplasia
Ductal Adenocarcinoma, Including Histologic Subtypes
Undifferentiated Carcinoma
Adenosquamous Carcinoma, Pancreas
Acinar Cell Carcinoma
Serous Cystadenoma
Acinar Cystic Transformation of the Pancreas
Well-Differentiated Neuroendocrine Tumor, Pancreas
Poorly Differentiated Neuroendocrine Carcinoma, Pancreas
Genomic Diagnosis of Intrahepatic Hepatobiliary Tumors
Role of Genomics in Diagnosis of Pancreaticobiliary Tumors
Simple Mucinous Cyst
Mucinous Cystic Neoplasm, Pancreas
Intraductal Papillary Mucinous Neoplasm
Intraductal Oncocytic Papillary Neoplasm
Intraductal Tubulopapillary Neoplasm
Solid Pseudopapillary Neoplasm
Pancreatoblastoma
Dermoid Cyst
Specimen Handling, Whipple
SECTION 6: TUMORS OF THE AMPULLA
Ampullary Adenoma
Ampullary Adenocarcinoma and Histologic Subtypes
Well-Differentiated Neuroendocrine Tumor, Ampulla
Composite Gangliocytoma/Neuroma and Neuroendocrine Tumor/Gangliocytic Paraganglioma
Review of the previous edition:
"The lists of differentials are incredibly helpful during diagnostic workup and to educate readers about similar entities that should be considered. The diagnostic checklists are especially helpful and emphasize important pathologic features and interpretation pearls. I strongly recommend this book to everyone interested in learning and reviewing hepatobiliary and pancreatic pathology." --©Doody’s Review Service, 2022, Jiayun Fang, MD (University of Michigan Medical School) Doody's Score: 5 Stars!
"The lists of differentials are incredibly helpful during diagnostic workup and to educate readers about similar entities that should be considered. The diagnostic checklists are especially helpful and emphasize important pathologic features and interpretation pearls. I strongly recommend this book to everyone interested in learning and reviewing hepatobiliary and pancreatic pathology." --©Doody’s Review Service, 2022, Jiayun Fang, MD (University of Michigan Medical School) Doody's Score: 5 Stars!
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