SECTION I Essential Renal Anatomy and Physiology
1 Renal Anatomy, 1
2 Renal Physiology, 14
SECTION II Investigation of Renal Disease
3 Assessment of Glomerular Filtration Rate, 29
4 Urinalysis, 39
5 Imaging, 53
6 Renal Biopsy, 72
SECTION III Fluid and Electrolyte Disorders
7 Disorders of Extracellular Volume, 80
8 Disorders of Water Metabolism, 94
9 Disorders of Potassium Metabolism, 111
10 Disorders of Calcium, Phosphate, and Magnesium Metabolism, 124
11 Normal Acid-Base Balance, 142
12 Metabolic Acidosis, 149
13 Metabolic Alkalosis, 160
14 Respiratory Acidosis, Respiratory Alkalosis, and Mixed Disorders, 170
SECTION IV Glomerular Disease
15 Introduction to Glomerular Disease: Clinical Presentations, 184
16 Introduction to Glomerular Disease: Histologic Classification and Pathogenesis, 199
17 Minimal Change Disease, 209
18 Primary and Secondary (Non-Genetic) Causes of Focal and Segmental Glomerulosclerosis, 219
19 Inherited Causes of Nephrotic Syndrome, 232
20 Membranous Nephropathy, 240
21 Membranoproliferative Glomerulonephritis and Cryoglobulinemic Glomerulonephritis, 254
22 Glomerulonephritis Associated With Complement Disorders, 263
23 Immunoglobulin A Nephropathy and IgA Vasculitis (Henoch-Schönlein Purpura), 270
24 Anti–Glomerular Basement Membrane Disease and Goodpasture Disease, 281
25 Renal and Systemic Vasculitis, 290
26 Lupus Nephritis, 306
27 Renal Amyloidosis and Glomerular Diseases With Monoclonal Immunoglobulin Deposition, 320
28 Rare Glomerular Disorders, 333
29 Thrombotic Microangiopathies, Including Hemolytic Uremic Syndrome, 343
SECTION V Diabetic Kidney Disease
30 Pathogenesis, Clinical Manifestations, and Natural History of Diabetic Kidney Disease, 357
31 Prevention and Treatment of Diabetic Kidney Disease, 376
32 Management of the Diabetic Patient With Chronic Kidney Disease, 385
SECTION VI Hypertension
33 Normal Blood Pressure Control and the Evaluation of Hypertension, 396
34 Primary Hypertension, 412
35 Nonpharmacologic Prevention and Treatment of Hypertension, 422
36 Pharmacologic Treatment of Hypertension, 430
37 Evaluation and Treatment of Hypertensive Emergencies and Urgencies, 444
38 Endocrine Causes of Hypertension: Aldosterone, 453
39 Other Endocrine Causes of Hypertension, 463
40 Neurogenic Hypertension, Including Hypertension Associated With Stroke or Spinal Cord Injury, 473
SECTION VII Renovascular Disease
41 Renovascular Hypertension and Ischemic
Nephropathy, 482
SECTION VIII Pregnancy and Renal Disease
42 Renal Physiology and Complications in Normal Pregnancy, 502
43 Pregnancy With Preexisting Kidney Disease, 522
SECTION IX Hereditary and Congenital Diseases of the Kidney
44 Autosomal Dominant Polycystic Kidney Disease, 532
45 Other Cystic Kidney Diseases, 545
46 Alport Syndrome and Other Familial Glomerular Syndromes, 560
47 Inherited Disorders of Sodium and Water Handling, 575
48 Fanconi Syndrome and Other Proximal Tubule Disorders, 586
49 Sickle Cell Diseases and the Kidney, 597
50 Congenital Anomalies of the Kidney and Urinary Tract, 607
SECTION X Infectious Diseases and the Kidney
51 Urinary Tract Infections in Adults, 626
52 Tuberculosis of the Urinary Tract, 639
53 Fungal Infections of the Urinary Tract, 650
54 The Kidney in Schistosomiasis, 655
55 Glomerular Diseases Associated With Infection, 664
56 Human Immunodeficiency Virus Infection and the Kidney, 679
SECTION XI Urologic Disorders
57 Nephrolithiasis and Nephrocalcinosis, 689
58 Urinary Tract Obstruction, 704
59 Urologic Issues for the Nephrologist, 717
SECTION XII Tubulointerstitial and Vascular Diseases
60 Acute Interstitial Nephritis, 729
61 Primary Vesicoureteral Reflux and Reflux Nephropathy, 738
62 Chronic Interstitial Nephritis, 748
63 Endemic Nephropathies, 761
64 Myeloma and the Kidney, 767
SECTION XIII Renal Disease and Cancer
65 Onconephrology: Kidney Disease in Cancer Patients, 776
SECTION XIV Acute Kidney Injury
66 Pathophysiology and Etiology of Acute Kidney Injury, 786
67 Acute Kidney Injury in the Tropics, 802
68 Diagnosis and Clinical Evaluation of Acute Kidney Injury, 810
69 Epidemiology and Prognostic Impact of Acute Kidney Injury, 820
70 Prevention and Nondialytic Management of Acute Kidney Injury, 825
71 Dialytic Management of Acute Kidney Injury and Intensive Care Unit Nephrology, 838
72 Dialytic Management of Refractory Heart Failure, 852
73 Hepatorenal Syndrome, 859
SECTION XV Drug Therapy in Kidney Disease
74 Principles of Drug Therapy, Dosing, and Prescribing in Chronic Kidney Disease and Renal Replacement Therapy, 870
75 Common Issues in Prescribing in Kidney Disease and Renal Replacement Therapy, 880
76 Herbal and Over-the-Counter Medicines and the Kidney, 894
SECTION XVI Chronic Kidney Disease and the Uremic Syndrome
77 Epidemiology of Chronic Kidney Disease and Dialysis, 903
78 Pathophysiology of Disease Progression in Proteinuric and Nonproteinuric Kidney Disease, 913
79 Retarding Progression of Kidney Disease, 924
80 Clinical Evaluation and Management of Chronic Kidney Disease, 935
81 Cardiovascular Disease in Chronic Kidney Disease, 942
82 Anemia in Chronic Kidney Disease, 958
83 Other Blood and Immune Disorders in Chronic Kidney Disease, 967
84 Bone and Mineral Disorders in Chronic Kidney Disease, 979
85 Neurologic Complications of Chronic Kidney Disease, 996
86 Gastroenterology and Nutrition in Chronic Kidney Disease, 1002
87 Dermatologic Manifestations of Chronic Kidney Disease, 1013
88 Acquired Cystic Kidney Disease and Malignant Neoplasms, 1022
SECTION XVII Geriatric and Palliative Nephrology
89 Geriatric Nephrology, 1028
SECTION XVIII Dialytic Therapies
90 Approach to Renal Replacement Therapy, 1036
91 Vascular Access for Dialytic Therapies, 1050
92 Diagnostic and Interventional Nephrology, 1062
93 Hemodialysis: Principles and Techniques, 1073
94 Hemodialysis: Dialysis Prescription and Adequacy, 1082
95 Acute Complications During Hemodialysis, 1090
96 Peritoneal Dialysis: Principles, Techniques, and Adequacy, 1103
97 Complications of Peritoneal Dialysis, 1114
98 Extracorporeal Therapies for Drug Overdose and Poisoning, 1124
99 Plasma Exchange, 1132
SECTION XIX Transplantation
100 Immunologic Principles in Kidney Transplantation, 1141
101 Immunosuppressive Medications in Kidney Transplantation, 1154
102 Evaluation and Preoperative Management of Kidney Transplant Recipient and Donor, 1163
103 Kidney Transplantation Surgery, 1174
104 Prophylaxis and Treatment of Kidney Transplant Rejection, 1186
105 Medical Management of the Kidney Transplant Recipient: Infections and Malignancies, 1198
106 Medical Management of the Kidney Transplant Recipient: Cardiovascular Disease and Metabolic
Abnormalities, 1213
107 Chronic Allograft Injury, 1226
108 Recurrent Disease in Kidney Transplantation, 1236
109 Outcomes of Renal Transplantation, 1247
110 Pancreas and Islet Transplantation, 1258
111 Kidney Disease in Liver, Cardiac, Lung, and Hematopoietic Stem Cell Transplantation, 1272
SECTION XX Palliative Nephrology
112 Palliative Nephrology, 1282
Index, 1289
