A masterful introduction to the cell biology that you need to know! This critically acclaimed textbook offers you a modern and unique approach to the study of cell biology. It emphasizes that cellular structure, function, and dysfunction ultimately result from specific macromolecular interactions. You'll progress from an explanation of the "hardware" of molecules and cells to an understanding of how these structures function in the organism in both healthy and diseased states. The exquisite art program helps you to better visualize molecular structures.
Covers essential concepts in a more efficient, reader-friendly manner than most other texts on this subject.
Makes cell biology easier to understand by demonstrating how cellular structure, function, and dysfunction result from specific macromole¬cular interactions.
Progresses logically from an explanation of the "hardware" of molecules and cells to an understanding of how these structures function in the organism in both healthy and diseased states.
Helps you to visualize molecular structures and functions with over 1500 remarkable full-color illustrations that present physical structures to scale.
Explains how molecular and cellular structures evolved in different organisms.
Shows how molecular changes lead to the development of diseases through numerous Clinical Examples throughout.
Includes STUDENT CONSULT access at no additional charge, enabling you to consult the textbook online, anywhere you go
New to this Edition
New keystone chapter on the origin and evolution of life on earth probably the best explanation of evolution for cell biologists available!
Spectacular new artwork by gifted artist Graham Johnson of the Scripps Research Institute in San Diego. 200 new and 500 revised figures bring his keen insight to Cell Biology illustration and further aid the reader's understanding.
New chapters and sections on the most dynamic areas of cell biology - Organelles and membrane traffic by Jennifer Lippincott-Schwartz; RNA processing (including RNAi) by David Tollervey., updates on stem cells and DNA Repair.
,More readable than ever. Improved organization and an accessible new design increase the focus on understanding concepts and mechanisms.
New guide to figures featuring specific organisms and specialized cells paired with a list of all of the figures showing these organisms. Permits easy review of cellular and molecular mechanisms.
New glossary with one-stop definitions of over 1000 of the most important terms in cell biology.
SECTION IV: Chromatin, Chromosomes, and the Cell Nucleus
CHAPTER 12 Chromosome Organization CHAPTER 13 DNA Packaging in Chromatin and Chromosomes CHAPTER 14 Nuclear Structure and Dynamics
SECTION V: Central Dogma: From Gene to Protein
CHAPTER 15 Gene Expression This chapter was written by Jeffrey L. Corden CHAPTER 16 Eukaryotic RNA Processing This chapter was written by David Tollervey CHAPTER 17 Protein Synthesis and Folding
SECTION VI: Cellular Organelles and Membrane Trafficking
CHAPTER 18 Posttranslational Targeting of Proteins CHAPTER 19 Mitochondria, Chloroplasts, Peroxisomes CHAPTER 20 Endoplasmic Reticulum CHAPTER 21 Secretory Membrane System and Golgi Apparatus CHAPTER 22 Endocytosis and the Endosomal Membrane System CHAPTER 23 Degradation of Cellular Components SECTION VII Signaling Mechanisms CHAPTER 24 Plasma Membrane Receptors CHAPTER 25 Protein Hardware for Signaling CHAPTER 26 Second Messengers CHAPTER 27 Integration of Signals
SECTION VIII: Cellular Adhesion and the Extracellular Matrix
CHAPTER 28 Cells of the Extracellular Matrix and Immune System CHAPTER 29 Extracelluar Matrix Molecules CHAPTER 30 Cellular Adhesion CHAPTER 31 Intercellular Junctions CHAPTER 32 Connective Tissues
SECTION IX: Cytoskeleton and Cellular Motility
CHAPTER 33 Actin and Actin-Binding Proteins CHAPTER 34 Microtubules and Centrosomes CHAPTER 35 Intermediate Filaments CHAPTER 36 Motor Proteins CHAPTER 37 Intracellular Motility CHAPTER 38 Cellular Motility CHAPTER 39 Muscles
SECTION X: Cell Cycle
CHAPTER 40 Introduction to the Cell Cycle CHAPTER 41 G1 Phase and Regulation of Cell Proliferation CHAPTER 42 S Phase and DNA Replication CHAPTER 43 G2 Phase and Control of Entry into Mitosis CHAPTER 44 Mitosis and Cytokinesis CHAPTER 45 Meiosis CHAPTER 46 Programmed Cell Death
By Thomas D. Pollard, MD, Professor, Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT; William C. Earnshaw, PhD, FRSE, Professor and Wellcome Principal Fellow, Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh, UK; Jennifer Lippincott-Schwartz, PhD, Head, Section on Organelle Biology, Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Bethesda, MD; Thomas D. Pollard, MD, Professor, Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT; William C. Earnshaw, PhD, FRSE, Professor and Wellcome Principal Fellow, Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh, UK and Jennifer Lippincott-Schwartz, PhD, Head, Section on Organelle Biology, Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Bethesda, MD
276 x 216 (8 1/2 x 10 7/8)
Please allow 3 - 4 weeks for delivery.
"This book contains everything you want to know and more about cells. Each section covers a topic by beginning with the basic molecules and background principles and then continuing up to how these give full physiological function. It is well designed because it contains lots of detail on each subject without drowning out key information for understanding. There are separate boxes on most pages, containing key principles and helpful summary tables alongside many excellent diagrams and research figures. It has been updated from the first edition with the inclusion of the latest research findings and there has also been an effort made to reduce jargon. I would recommend this book for a person wanting to conduct research who needs solid baseline knowledge of cell biology." Medical Student, Leicester Medical School, UK