Ever since the discovery of blood types early in the last century, transfusion medicine has evolved at a breakneck pace. This second edition of Blood Banking and Transfusion Medicine is exactly what you need to keep up. It combines scientific foundations with today's most practical approaches to the specialty. From blood collection and storage to testing and transfusing blood components, and finally cellular engineering, you'll find coverage here that's second to none. New advances in molecular genetics and the scientific mechanisms underlying the field are also covered, with an emphasis on the clinical implications for treatment. Whether you're new to the field or an old pro, this book belongs in your reference library.
Integrates scientific foundations with clinical relevance to more clearly explain the science and its application to clinical practice.
Highlights advances in the use of blood products and new methods of disease treatment while providing the most up-to-date information on these fast-moving topics
New to this Edition
Discusses current clinical controversies, providing an arena for the discussion of sensitive topics.
Covers the constantly changing approaches to stem cell transplantation and brings you the latest information on this controversial topic.
2. Principles of the Immune System Central to Transfusion Medicine 3. Principles of the Complement System Central to Transfusion Medicine 4. Principles of Red Blood Cell Allo- and Autoantibody Formation and Function
ii. Red Blood Cell, Platelet and Leukocyte Antigens and Antibodies
5. Membrane Blood Group Antigens and Antibodies 6. ABO and Related Antigens and Antibodies 7. Rh, Kell, Duffy, and Kidd Antigens and Antibodies 8. Other Blood Group Antigens and Antibodies 9. Human Platelet Antigens and Antibodies 10. HLA and Granulocyte Antigens and Antibodies
B. Blood Donation, Manufacturing, Testing and Storage
11. Blood Donation and Collection 12. Blood Manufacturing: Component Preparation, Storage and Transportation 13. Red Blood Cell Metabolism During Storage: Basic Principles and Practical Aspects 14. Infectious Disease Testing: Basic Principles and Practical Aspects
C. Regulatory, Quality and Legal Principles
15. Regulatory Principles and Issues Central to Blood Banking and Transfusion Medicine 16. Quality Assurance, Control and Improvement and Accreditation 17. Legal Principles and Issues Central to Transfusion Medicine
D. Specific Blood Components
18. Packed Red Blood Cell and Related Products 19. Fresh Frozen Plasma and Related Products 20. Cryoprecipitate and Related Products 21. Albumin 22. IVIg and Derivatives 23. Platelets and Related Products 24. Granulocytes 25. Coagulation Factor Preparations
E. Special Processes and Products
26. Leukocyte Reduced Products 27. Virus Safe Products: Pathogen Reduction and Inactivation 28. Irradiated Products 29. Washed and/or Volume Reduced Blood Components 30. Blood Management: Conservation, Salvage and Alternatives to Allogeneic Transfusion 31. Blood Substitutes: Basic Principles and Pracitcal Aspects
III. Transfusion Medicine
A. Transfusion in Specific Clinical Settings
32. Red Blood Cell Transfusion: Surgical and Traumatic Blood Loss and Anemia 33. Post-Transfusion Red Blood Cell and Platelet Survical and Kinetics: Basic Principles and Practical Aspects 34. Transfusion of the Patient with Congenital Coagulation Defects 35. Transfusion of the Patient with Acquired Coagulation Defects 36. Obstetric and Intrauterine Transfusion 37. Transfusion of the Neonates and Pediatric Patients 38. Transfusion of the Hemoglobinopathy Patient 39. Transfusion to Bone Marrow or Solid Organ Transplant Recipients 40. Transfusion of the Platelet Refractory Patient 41. Transfusion of the Patient with an Autoimmune Hemolytic Anemia 42. Transfusion in Economically-Restricted Countries and Developing Countries
B. Complications of Transfusion
i. Infectious Complications
43. Hepatitis A, B, and Non-A, Non-B, Non-C Viruses 44. Hepatitis C 45. HIV, HTLV, and Other Retroviruses 46. Human Herpesvirus Infections 47. Bacterial Infections: Bacterial Contamination, Testing and Post Transfusion Complications 48. Other Viral, Bacterial and Prion-Based Infectious Complications
ii. Non-Infectious Complications
49. Acute and Delayed Hemolytic Transfusion Reactions 50. Febrile, Allergic, and Other Noninfectious Transfusion Reactions 51. Transfusion-Related Acute Lung Injury 52. Transfusion-Related Immunomodulation 53. Post-Transfusion Engraftment Syndromes: Microchimerism and TA-GvHD
57. The Role of Transfusion Medicine in Cellular Therapies 58. Bone Marrow and Peripheral Blood Stem Cells: Collection, Processing and Transfusion 59. Umbilical Cord Blood Stem Cells: Collection, Processing and Transfusion 60. Mononuclear Cell-Based Preparations 61. Tissue Banking in the Hospital Setting
By Christopher D. Hillyer, MD, Director, Transfusion Medicine Program; Professor, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA; Leslie E. Silberstein, MD, Director, Joint Program in Transfusion Medicine, Children's Hospital Boston, Dana-Farber Cancer Institute, And Brigham and Women's Hospital; Professor of Pathology (Pediatrics), Harvard Medical School, Boston, MA; Paul M. Ness, MD, Director, Transfusion Medicine Division, Johns Hopkins Medical Institutions; Professor, Pathology, Medicine, and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Kenneth C. Anderson, MD, Chief, Division of Hematologic Neoplasia; Director, Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute; Kraft Family Professor of Medicine, Joint Program in Transfusion Medicine, Harvard Medical School, Boston, MA; and John D. Roback, MD, PhD, Associate Director, Transfusion Medicine Program; Associate Professor, Department of Pathology and Laboratory Medicine, Emory University, School of Medicine, Atlanta, GA, USA